Human herpesvirus 6B infection of the large intestine of patients with diarrhea.

نویسندگان

Kiyoko Amo

Keiko Tanaka-Taya

Reiko Inagi

Hiromi Miyagawa

Hiroko Miyoshi

Ikuko Okusu

Junji Sashihara

Junichi Hara

Masahiro Nakayama

Koichi Yamanishi

Shintaro Okada

چکیده

Four patients had severe diarrhea after undergoing stem cell transplantation. Human herpesvirus 6B (HHV-6B) DNA was detected in large intestine tissue specimens and in peripheral blood mononuclear cells. In situ hybridization was positive for HHV-6B DNA in the nuclei of goblet cells and, sometimes, in the histiocytes in the submucous region of the large intestine, which suggests that HHV-6B may infect and reactivate in these cells.

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